There should be no technical reason why it could not be done, as long as the right ports were opened across the firewall between the two domains, but there may be security reasons for not wanting to do so. I recommend that you read the relevant sections of the whitepaper that can be found at: https://devcentral.symbol.com/article.aspx?id=19792&ac=1. This should explain what would need to be done and also highlight the potential security implications of doing so.